Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 21/07/21 03:00 | 21/07/21 03:00 | Vancouver Whitecaps | Houston Dynamo | 0-0 | 4 - 5 - 4 |
| 22/07/21 00:30 | 22/07/21 00:30 | New York City FC | CF Montreal | 1-0 | 3 - 5 - 5 |
| 22/07/21 00:30 | 22/07/21 00:30 | Toronto FC | New York Red Bulls | 1-1 | 4 - 5 - 4 |
| 22/07/21 00:30 | 22/07/21 00:30 | Inter Miami CF | New England Revolution | 0-5 | 4 - 5 - 3 |
| 22/07/21 00:30 | 22/07/21 00:30 | Columbus Crew | Nashville SC | 0-0 | 3 - 4 - 5 |
| 22/07/21 01:00 | 22/07/21 01:00 | Cincinnati FC | Atlanta United FC | 1-1 | 3 - 5 - 4 |
| 22/07/21 01:00 | 22/07/21 01:00 | Chicago Fire | D.C. United | 2-2 | 3 - 5 - 5 |
| 22/07/21 01:30 | 22/07/21 01:30 | Sporting Kansas City | San Jose Earthquakes | 1-1 | 3 - 5 - 5 |
| 22/07/21 02:00 | 22/07/21 02:00 | Colorado Rapids | FC Dallas | 2-0 | 3 - 5 - 5 |
| 22/07/21 03:00 | 22/07/21 03:00 | Real Salt Lake | Los Angeles Galaxy | 2-2 | 3 - 5 - 4 |
| 22/07/21 03:30 | 22/07/21 03:30 | Portland Timbers | Los Angeles FC | 2-1 | 5 - 5 - 3 |
| 23/07/21 00:30 | 23/07/21 00:30 | Orlando City | Philadelphia Union | 2-1 | 3 - 5 - 5 |
| 23/07/21 02:30 | 23/07/21 02:30 | Austin FC | Seattle Sounders | 0-1 | 5 - 5 - 3 |