Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| MLS | 05/05/22 00:30 | 05/05/22 00:30 | Cincinnati FC | Toronto FC | 2-0 | 4 - 5 - 4 |
| MLS | 19/05/22 00:30 | 19/05/22 00:30 | D.C. United | New York City FC | 0-2 | 5 - 5 - 3 |
| MLS | 19/05/22 00:30 | 19/05/22 00:30 | Philadelphia Union | Inter Miami CF | 0-0 | 3 - 5 - 5 |
| MLS | 19/05/22 00:30 | 19/05/22 00:30 | New York Red Bulls | Chicago Fire | 3-3 | 3 - 5 - 5 |
| MLS | 19/05/22 01:00 | 19/05/22 01:00 | Minnesota United FC | Los Angeles Galaxy | 1-1 | 5 - 5 - 3 |
| MLS | 19/05/22 01:30 | 19/05/22 01:30 | Houston Dynamo | Seattle Sounders | 0-1 | 5 - 5 - 3 |
| MLS | 19/05/22 01:30 | 19/05/22 01:30 | Nashville SC | CF Montreal | 2-1 | 3 - 5 - 4 |
| MLS | 19/05/22 01:30 | 19/05/22 01:30 | Sporting Kansas City | Colorado Rapids | 2-1 | 4 - 5 - 4 |
| MLS | 19/05/22 03:00 | 19/05/22 03:00 | Vancouver Whitecaps | FC Dallas | 2-1 | 4 - 5 - 3 |
| MLS | 19/05/22 03:30 | 19/05/22 03:30 | Los Angeles FC | Austin FC | 1-2 | 3 - 5 - 5 |
| MLS | 19/05/22 03:30 | 19/05/22 03:30 | San Jose Earthquakes | Portland Timbers | 3-2 | 5 - 4 - 3 |