Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/06/21 20:00 | 12/06/21 20:00 | Sporting Kansas City | Austin FC | 1-1 | 3 - 5 - 5 |
| 17/07/21 22:00 | 17/07/21 22:00 | Atlanta United FC | New England Revolution | 0-1 | 4 - 5 - 4 |
| 18/07/21 00:30 | 18/07/21 00:30 | CF Montreal | Cincinnati FC | 5-4 | 3 - 5 - 5 |
| 18/07/21 00:30 | 18/07/21 00:30 | Toronto FC | Orlando City | 1-1 | 4 - 4 - 4 |
| 18/07/21 00:30 | 18/07/21 00:30 | Philadelphia Union | D.C. United | 2-1 | 3 - 5 - 5 |
| 18/07/21 00:30 | 18/07/21 00:30 | Columbus Crew | New York City FC | 2-1 | 3 - 5 - 5 |
| 18/07/21 01:30 | 18/07/21 01:30 | Nashville SC | Chicago Fire | 5-1 | 3 - 5 - 5 |
| 18/07/21 02:00 | 18/07/21 02:00 | Colorado Rapids | San Jose Earthquakes | 1-1 | 3 - 5 - 5 |
| 18/07/21 03:00 | 18/07/21 03:00 | Vancouver Whitecaps | Los Angeles Galaxy | 2-1 | 5 - 5 - 3 |
| 18/07/21 03:30 | 18/07/21 03:30 | Los Angeles FC | Real Salt Lake | 2-1 | 3 - 5 - 5 |
| 18/07/21 03:30 | 18/07/21 03:30 | Portland Timbers | FC Dallas | 1-0 | 3 - 5 - 5 |
| 18/07/21 19:00 | 18/07/21 19:00 | Minnesota United FC | Seattle Sounders | 1-0 | 5 - 5 - 3 |
| 09/10/21 23:00 | 09/10/21 23:00 | New York Red Bulls | Inter Miami CF | 1-0 | 3 - 5 - 5 |