Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 08/07/21 00:00 | 08/07/21 00:00 | New England Revolution | Toronto FC | 2-3 | 3 - 5 - 5 |
| 08/07/21 00:30 | 08/07/21 00:30 | CF Montreal | New York City FC | 2-1 | 5 - 4 - 3 |
| 08/07/21 01:00 | 08/07/21 01:00 | Chicago Fire | Orlando City | 3-1 | 4 - 5 - 3 |
| 08/07/21 02:00 | 08/07/21 02:00 | Austin FC | Los Angeles FC | 0-2 | 4 - 5 - 3 |
| 08/07/21 02:00 | 08/07/21 02:00 | Seattle Sounders | Houston Dynamo | 2-0 | 3 - 5 - 5 |
| 08/07/21 02:00 | 08/07/21 02:00 | Colorado Rapids | Minnesota United FC | 2-0 | 3 - 5 - 5 |
| 08/07/21 03:00 | 08/07/21 03:00 | Vancouver Whitecaps | Real Salt Lake | 0-4 | 5 - 5 - 3 |
| 08/07/21 03:30 | 08/07/21 03:30 | Los Angeles Galaxy | FC Dallas | 3-1 | 3 - 5 - 5 |
| 09/07/21 01:00 | 09/07/21 01:00 | New York Red Bulls | Philadelphia Union | 1-1 | 3 - 5 - 5 |
| 09/07/21 01:30 | 09/07/21 01:30 | Nashville SC | Atlanta United FC | 2-2 | 3 - 5 - 5 |
| 10/07/21 00:30 | 10/07/21 00:30 | Cincinnati FC | Columbus Crew | 2-2 | 5 - 5 - 3 |