Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 02/07/21 02:30 | 02/07/21 02:30 | Austin FC | Portland Timbers | 4-1 | 5 - 5 - 3 |
| 03/07/21 22:00 | 03/07/21 22:00 | Columbus Crew | New England Revolution | 2-2 | 4 - 5 - 4 |
| 03/07/21 22:30 | 03/07/21 22:30 | D.C. United | Toronto FC | 7-1 | 3 - 5 - 5 |
| 04/07/21 00:30 | 04/07/21 00:30 | CF Montreal | Inter Miami CF | 1-0 | 3 - 5 - 4 |
| 04/07/21 00:30 | 04/07/21 00:30 | Orlando City | New York Red Bulls | 1-2 | 3 - 5 - 5 |
| 04/07/21 01:00 | 04/07/21 01:00 | Nashville SC | Philadelphia Union | 1-0 | 4 - 4 - 4 |
| 04/07/21 01:00 | 04/07/21 01:00 | Minnesota United FC | San Jose Earthquakes | 2-2 | 3 - 5 - 5 |
| 04/07/21 01:00 | 04/07/21 01:00 | Chicago Fire | Atlanta United FC | 3-0 | 4 - 5 - 3 |
| 04/07/21 01:30 | 04/07/21 01:30 | Houston Dynamo | Cincinnati FC | 1-1 | 3 - 5 - 5 |
| 04/07/21 03:00 | 04/07/21 03:00 | Real Salt Lake | Los Angeles FC | 0-1 | 4 - 5 - 3 |
| 05/07/21 01:30 | 05/07/21 01:30 | FC Dallas | Vancouver Whitecaps | 2-2 | 3 - 5 - 5 |
| 05/07/21 02:00 | 05/07/21 02:00 | Colorado Rapids | Seattle Sounders | 1-1 | 5 - 5 - 3 |
| 05/07/21 03:30 | 05/07/21 03:30 | Los Angeles Galaxy | Sporting Kansas City | 0-2 | 3 - 5 - 5 |