Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| MLS | 30/04/22 18:30 | 30/04/22 18:30 | Houston Dynamo | Austin FC | 1-2 | 3 - 5 - 4 |
| MLS | 30/04/22 20:00 | 30/04/22 20:00 | Toronto FC | Cincinnati FC | 1-2 | 3 - 5 - 5 |
| MLS | 30/04/22 20:30 | 30/04/22 20:30 | Real Salt Lake | Los Angeles Galaxy | 1-0 | 5 - 5 - 3 |
| MLS | 30/04/22 21:00 | 30/04/22 21:00 | CF Montreal | Atlanta United FC | 2-1 | 3 - 4 - 5 |
| MLS | 01/05/22 00:30 | 01/05/22 00:30 | Columbus Crew | D.C. United | 3-0 | 3 - 5 - 5 |
| MLS | 01/05/22 00:30 | 01/05/22 00:30 | New England Revolution | Inter Miami CF | 2-0 | 3 - 5 - 5 |
| MLS | 01/05/22 00:30 | 01/05/22 00:30 | Orlando City | Charlotte FC | 2-1 | 3 - 5 - 5 |
| MLS | 01/05/22 01:00 | 01/05/22 01:00 | Chicago Fire | New York Red Bulls | 1-2 | 4 - 5 - 3 |
| MLS | 01/05/22 01:30 | 01/05/22 01:30 | Sporting Kansas City | FC Dallas | 2-2 | 3 - 5 - 4 |
| MLS | 01/05/22 02:00 | 01/05/22 02:00 | Colorado Rapids | Portland Timbers | 2-0 | 4 - 4 - 4 |
| MLS | 01/05/22 18:00 | 01/05/22 18:00 | New York City FC | San Jose Earthquakes | 3-0 | 3 - 5 - 5 |
| MLS | 01/05/22 21:00 | 01/05/22 21:00 | Nashville SC | Philadelphia Union | 1-1 | 4 - 5 - 3 |
| MLS | 02/05/22 03:00 | 02/05/22 03:00 | Los Angeles FC | Minnesota United FC | 2-0 | 3 - 5 - 5 |
| MLS | 15/06/22 03:30 | 15/06/22 03:30 | Seattle Sounders | Vancouver Whitecaps | 4-0 | 3 - 5 - 5 |