Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 26/06/21 01:00 | 26/06/21 01:00 | Inter Miami CF | Orlando City | 1-2 | 5 - 5 - 3 |
| 26/06/21 22:30 | 26/06/21 22:30 | Sporting Kansas City | Los Angeles FC | 2-1 | 3 - 5 - 4 |
| 27/06/21 00:00 | 27/06/21 00:00 | Toronto FC | Cincinnati FC | 0-2 | 3 - 5 - 5 |
| 27/06/21 01:00 | 27/06/21 01:00 | Real Salt Lake | Houston Dynamo | 1-1 | 3 - 5 - 4 |
| 27/06/21 01:00 | 27/06/21 01:00 | Chicago Fire | Philadelphia Union | 3-3 | 4 - 5 - 3 |
| 27/06/21 01:30 | 27/06/21 01:30 | Nashville SC | CF Montreal | 1-1 | 3 - 5 - 5 |
| 27/06/21 02:00 | 27/06/21 02:00 | Seattle Sounders | Vancouver Whitecaps | 2-2 | 3 - 5 - 5 |
| 27/06/21 03:00 | 27/06/21 03:00 | San Jose Earthquakes | Los Angeles Galaxy | 1-3 | 5 - 5 - 3 |
| 27/06/21 04:30 | 27/06/21 04:30 | Portland Timbers | Minnesota United FC | 0-1 | 3 - 5 - 5 |
| 27/06/21 20:30 | 27/06/21 20:30 | Atlanta United FC | New York Red Bulls | 0-0 | 3 - 5 - 5 |
| 27/06/21 23:00 | 27/06/21 23:00 | New York City FC | D.C. United | 2-1 | 3 - 5 - 5 |
| 28/06/21 01:00 | 28/06/21 01:00 | Austin FC | Columbus Crew | 0-0 | 5 - 4 - 3 |
| 28/06/21 02:00 | 28/06/21 02:00 | FC Dallas | New England Revolution | 2-1 | 4 - 5 - 4 |