Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/04/21 01:00 | 17/04/21 01:00 | Houston Dynamo | San Jose Earthquakes | 2-1 | 3 - 5 - 5 |
| 17/04/21 02:30 | 17/04/21 02:30 | Seattle Sounders | Minnesota United FC | 4-0 | 3 - 5 - 5 |
| 17/04/21 19:00 | 17/04/21 19:00 | CF Montreal | Toronto FC | 4-2 | 5 - 5 - 3 |
| 17/04/21 20:00 | 17/04/21 20:00 | Orlando City | Atlanta United FC | 0-0 | 4 - 5 - 4 |
| 17/04/21 23:00 | 17/04/21 23:00 | Los Angeles FC | Austin FC | 2-0 | 3 - 5 - 5 |
| 18/04/21 01:00 | 18/04/21 01:00 | D.C. United | New York City FC | 2-1 | 5 - 5 - 3 |
| 18/04/21 01:00 | 18/04/21 01:00 | FC Dallas | Colorado Rapids | 0-0 | 3 - 5 - 5 |
| 18/04/21 01:00 | 18/04/21 01:00 | New York Red Bulls | Sporting Kansas City | 1-2 | 3 - 5 - 5 |
| 18/04/21 01:30 | 18/04/21 01:30 | Chicago Fire | New England Revolution | 2-2 | 5 - 5 - 3 |
| 18/04/21 01:30 | 18/04/21 01:30 | Nashville SC | Cincinnati FC | 2-2 | 3 - 5 - 5 |
| 18/04/21 20:20 | 18/04/21 20:20 | Inter Miami CF | Los Angeles Galaxy | 2-3 | 4 - 5 - 4 |
| 18/04/21 22:30 | 18/04/21 22:30 | Columbus Crew | Philadelphia Union | 0-0 | 3 - 5 - 5 |
| 19/04/21 03:00 | 19/04/21 03:00 | Vancouver Whitecaps | Portland Timbers | 1-0 | 5 - 5 - 3 |