| Date | Home | Away | Result |
|---|---|---|---|
| 14/10/22 19:30 | FC Schalke 04 | 1899 Hoffenheim | 0-3 |
| 15/10/22 14:30 | Eintracht Frankfurt | Bayer 04 Leverkusen | 5-1 |
| 15/10/22 14:30 | VfB Stuttgart | VfL Bochum | 4-1 |
| 15/10/22 14:30 | VfL Wolfsburg | Bor. Mönchengladbach | 2-2 |
| 15/10/22 14:30 | Werder Bremen | FSV Mainz 05 | 0-2 |
| 15/10/22 17:30 | RB Leipzig | Hertha BSC | 3-2 |
| 16/10/22 14:30 | 1. FC Köln | FC Augsburg | 3-2 |
| 16/10/22 16:30 | 1. FC Union Berlin | Borussia Dortmund | 2-0 |
| 16/10/22 18:30 | FC Bayern Munich | SC Freiburg | 5-0 |