Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/09/21 18:00 | 17/09/21 18:00 | Altay SK | Göztepe Izmir | 2-1 | 2 - 4 points |
| 17/09/21 18:00 | 17/09/21 18:00 | Yeni Malatyaspor | Fatih Karagümrük | 3-4 | 2 - 4 points |
| 18/09/21 11:30 | 18/09/21 11:30 | Sivasspor | Gazisehir Gaziantep FK | 1-1 | 2 - 4 points |
| 18/09/21 14:00 | 18/09/21 14:00 | Kasimpasa Istanbul | Trabzonspor | 0-1 | 2 - 4 points |
| 18/09/21 17:00 | 18/09/21 17:00 | Adana Demirspor | Caykur Rizespor | 3-1 | 2 - 4 points |
| 18/09/21 17:00 | 18/09/21 17:00 | Antalyaspor | Besiktas Istanbul | 2-3 | 2 - 4 points |
| 19/09/21 11:30 | 19/09/21 11:30 | Giresunspor | Konyaspor | 0-0 | 2 - 4 points |
| 19/09/21 14:00 | 19/09/21 14:00 | Galatasaray Istanbul | Alanyaspor | 0-1 | 2 - 4 points |
| 19/09/21 17:00 | 19/09/21 17:00 | Istanbul Basaksehir FK | Fenerbahce Istanbul | 2-0 | 2 - 4 points |
| 19/09/21 17:00 | 19/09/21 17:00 | Hatayspor | Kayserispor | 2-1 | 2 - 4 points |