Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/03/22 17:45 | 10/03/22 17:45 | PAOK Saloniki | KAA Gent | 1-0 | 2 - 4 points |
| 10/03/22 17:45 | 10/03/22 17:45 | Slavia Prag | Linzer ASK | 4-1 | 2 - 4 points |
| 10/03/22 17:45 | 10/03/22 17:45 | Vitesse Arnheim | AS Roma | 0-1 | 2 - 4 points |
| 10/03/22 17:45 | 10/03/22 17:45 | Partizan Belgrad | Feyenoord Rotterdam | 2-5 | 2 - 4 points |
| 10/03/22 20:00 | 10/03/22 20:00 | Olympique Marseille | FC Basel | 2-1 | 2 - 4 points |
| 10/03/22 20:00 | 10/03/22 20:00 | Leicester City | Stade Rennes | 2-0 | 2 - 4 points |
| 10/03/22 20:00 | 10/03/22 20:00 | PSV Eindhoven | FC Copenhagen | 4-4 | 2 - 4 points |
| 10/03/22 20:00 | 10/03/22 20:00 | FK Bodö/Glimt | AZ Alkmaar | 2-1 | 2 - 4 points |