Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/02/22 17:45 | 17/02/22 17:45 | PSV Eindhoven | Maccabi Tel Aviv | 1-0 | 2 - 4 points |
| 17/02/22 17:45 | 17/02/22 17:45 | FC Midtjylland | PAOK Saloniki | 1-0 | 2 - 4 points |
| 17/02/22 17:45 | 17/02/22 17:45 | SK Rapid Wien | Vitesse Arnheim | 2-1 | 2 - 4 points |
| 17/02/22 17:45 | 17/02/22 17:45 | Fenerbahce Istanbul | Slavia Prag | 2-3 | 2 - 4 points |
| 17/02/22 20:00 | 17/02/22 20:00 | Sparta Prag | Partizan Belgrad | 0-1 | 2 - 4 points |
| 17/02/22 20:00 | 17/02/22 20:00 | Celtic Glasgow | FK Bodö/Glimt | 1-3 | 2 - 4 points |
| 17/02/22 20:00 | 17/02/22 20:00 | Leicester City | Randers | 4-1 | 2 - 4 points |
| 17/02/22 20:00 | 17/02/22 20:00 | Olympique Marseille | Qarabag | 3-1 | 2 - 4 points |