Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 03/11/22 15:30 | 03/11/22 15:30 | Rigas Futbola Skola | Fiorentina | Group A | 0-3 | 2 - 4 points |
| 03/11/22 15:30 | 03/11/22 15:30 | Istanbul Basaksehir FK | Heart of Midlothian | Group A | 3-1 | 2 - 4 points |
| 03/11/22 17:45 | 03/11/22 17:45 | Zalgiris Vilnius | SK Slovan Bratislava | Group H | 1-2 | 2 - 4 points |
| 03/11/22 17:45 | 03/11/22 17:45 | Slavia Prag | Sivasspor | Group G | 1-1 | 2 - 4 points |
| 03/11/22 17:45 | 03/11/22 17:45 | Pyunik | FC Basel | Group H | 1-2 | 2 - 4 points |
| 03/11/22 17:45 | 03/11/22 17:45 | Djurgardens IF | Shamrock Rovers | Group F | 1-0 | 2 - 4 points |
| 03/11/22 17:45 | 03/11/22 17:45 | CFR Cluj | KF Ballkani Suhareka | Group G | 1-0 | 2 - 4 points |
| 03/11/22 17:45 | 03/11/22 17:45 | KAA Gent | Molde FK | Group F | 4-0 | 2 - 4 points |
| 03/11/22 17:45 | 03/11/22 17:45 | AZ Alkmaar | SK Dnipro-1 | Group E | 2-1 | 2 - 4 points |
| 03/11/22 17:45 | 03/11/22 17:45 | Apollon Limassol FC | FC Vaduz | Group E | 1-0 | 2 - 4 points |
| 03/11/22 20:00 | 03/11/22 20:00 | 1. FC Köln | OGC Nice | Group D | 2-2 | 2 - 4 points |
| 03/11/22 20:00 | 03/11/22 20:00 | Partizan Belgrad | 1. FC Slovacko | Group D | 1-1 | 2 - 4 points |
| 03/11/22 20:00 | 03/11/22 20:00 | Lech Poznan | FC Villarreal | Group C | 3-0 | 2 - 4 points |
| 03/11/22 20:00 | 03/11/22 20:00 | Hapoel Beer Sheva | FK Austria Wien | Group C | 4-0 | 2 - 4 points |
| 03/11/22 20:00 | 03/11/22 20:00 | FCSB Bukarest | West Ham United | Group B | 0-3 | 2 - 4 points |
| 03/11/22 20:00 | 03/11/22 20:00 | Silkeborg IF | RSC Anderlecht | Group B | 0-2 | 2 - 4 points |