Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 25/11/21 15:30 | 25/11/21 15:30 | Flora Tallinn | Partizan Belgrad | Group B | 1-0 | 2 - 4 points |
| 25/11/21 15:30 | 25/11/21 15:30 | Qairat Almaty | FC Basel | Group H | 2-3 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | HJK Helsinki | Alashkert Erewan | Group A | 1-0 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | Slavia Prag | Feyenoord Rotterdam | Group E | 2-2 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | Maccabi Haifa | 1. FC Union Berlin | Group E | 0-1 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | SK Slovan Bratislava | PAOK Saloniki | Group F | 0-0 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | Lincoln Red Imps FC | FC Copenhagen | Group F | 0-4 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | NS Mura | Tottenham Hotspur | Group G | 2-1 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | Stade Rennes | Vitesse Arnheim | Group G | 3-3 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | Qarabag | Omonia Nicosia | Group H | 2-2 | 2 - 4 points |
| 25/11/21 20:00 | 25/11/21 20:00 | Maccabi Tel Aviv | Linzer ASK | Group A | 0-1 | 2 - 4 points |
| 25/11/21 20:00 | 25/11/21 20:00 | Anorthosis Famagusta | KAA Gent | Group B | 1-0 | 2 - 4 points |
| 25/11/21 20:00 | 25/11/21 20:00 | FK Bodö/Glimt | ZSKA Sofia | Group C | 2-0 | 2 - 4 points |
| 25/11/21 20:00 | 25/11/21 20:00 | AS Roma | FC Zorya Lugansk | Group C | 4-0 | 2 - 4 points |
| 25/11/21 20:00 | 25/11/21 20:00 | Jablonec | AZ Alkmaar | Group D | 1-1 | 2 - 4 points |
| 25/11/21 20:00 | 25/11/21 20:00 | Randers | CFR Cluj | Group D | 2-1 | 2 - 4 points |