Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 27/10/22 17:45 | 27/10/22 17:45 | OGC Nice | Partizan Belgrad | Group D | 2-1 | 2 - 4 points |
| 27/10/22 17:45 | 27/10/22 17:45 | FK Austria Wien | Lech Poznan | Group C | 1-1 | 2 - 4 points |
| 27/10/22 17:45 | 27/10/22 17:45 | FC Villarreal | Hapoel Beer Sheva | Group C | 2-2 | 2 - 4 points |
| 27/10/22 17:45 | 27/10/22 17:45 | FC Vaduz | AZ Alkmaar | Group E | 1-2 | 2 - 4 points |
| 27/10/22 17:45 | 27/10/22 17:45 | RSC Anderlecht | FCSB Bukarest | Group B | 2-2 | 2 - 4 points |
| 27/10/22 17:45 | 27/10/22 17:45 | Fiorentina | Istanbul Basaksehir FK | Group A | 2-1 | 2 - 4 points |
| 27/10/22 20:00 | 27/10/22 20:00 | SK Slovan Bratislava | Pyunik | Group H | 2-1 | 2 - 4 points |
| 27/10/22 20:00 | 27/10/22 20:00 | FC Basel | Zalgiris Vilnius | Group H | 2-2 | 2 - 4 points |
| 27/10/22 20:00 | 27/10/22 20:00 | Sivasspor | CFR Cluj | Group G | 3-0 | 2 - 4 points |
| 27/10/22 20:00 | 27/10/22 20:00 | KF Ballkani Suhareka | Slavia Prag | Group G | 0-1 | 2 - 4 points |
| 27/10/22 20:00 | 27/10/22 20:00 | Shamrock Rovers | KAA Gent | Group F | 1-1 | 2 - 4 points |
| 27/10/22 20:00 | 27/10/22 20:00 | Molde FK | Djurgardens IF | Group F | 2-3 | 2 - 4 points |
| 27/10/22 20:00 | 27/10/22 20:00 | SK Dnipro-1 | Apollon Limassol FC | Group E | 1-0 | 2 - 4 points |
| 27/10/22 20:00 | 27/10/22 20:00 | West Ham United | Silkeborg IF | Group B | 1-0 | 2 - 4 points |
| 27/10/22 20:00 | 27/10/22 20:00 | Heart of Midlothian | Rigas Futbola Skola | Group A | 2-1 | 2 - 4 points |
| 28/10/22 12:00 | 28/10/22 12:00 | 1. FC Slovacko | 1. FC Köln | Group D | 0-1 | 2 - 4 points |