Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 04/11/21 15:30 | 04/11/21 15:30 | Flora Tallinn | Anorthosis Famagusta | Group B | 2-2 | 2 - 4 points |
| 04/11/21 15:30 | 04/11/21 15:30 | Qairat Almaty | Qarabag | Group H | 1-2 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | Maccabi Tel Aviv | HJK Helsinki | Group A | 3-0 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | Linzer ASK | Alashkert Erewan | Group A | 2-0 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | KAA Gent | Partizan Belgrad | Group B | 1-1 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | FC Zorya Lugansk | ZSKA Sofia | Group C | 2-0 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | AZ Alkmaar | CFR Cluj | Group D | 2-0 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | Randers | Jablonec | Group D | 2-2 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | Lincoln Red Imps FC | SK Slovan Bratislava | Group F | 1-4 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | Omonia Nicosia | FC Basel | Group H | 1-1 | 2 - 4 points |
| 04/11/21 20:00 | 04/11/21 20:00 | AS Roma | FK Bodö/Glimt | Group C | 2-2 | 2 - 4 points |
| 04/11/21 20:00 | 04/11/21 20:00 | 1. FC Union Berlin | Feyenoord Rotterdam | Group E | 1-2 | 2 - 4 points |
| 04/11/21 20:00 | 04/11/21 20:00 | Slavia Prag | Maccabi Haifa | Group E | 1-0 | 2 - 4 points |
| 04/11/21 20:00 | 04/11/21 20:00 | PAOK Saloniki | FC Copenhagen | Group F | 1-2 | 2 - 4 points |
| 04/11/21 20:00 | 04/11/21 20:00 | Stade Rennes | NS Mura | Group G | 1-0 | 2 - 4 points |
| 04/11/21 20:00 | 04/11/21 20:00 | Tottenham Hotspur | Vitesse Arnheim | Group G | 3-2 | 2 - 4 points |