Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 13/10/22 17:45 | 13/10/22 17:45 | SK Slovan Bratislava | FC Basel | Group H | 3-3 | 2 - 4 points |
| 13/10/22 17:45 | 13/10/22 17:45 | Partizan Belgrad | 1. FC Köln | Group D | 2-0 | 2 - 4 points |
| 13/10/22 17:45 | 13/10/22 17:45 | CFR Cluj | Slavia Prag | Group G | 2-0 | 2 - 4 points |
| 13/10/22 17:45 | 13/10/22 17:45 | Djurgardens IF | KAA Gent | Group F | 4-2 | 2 - 4 points |
| 13/10/22 17:45 | 13/10/22 17:45 | FK Austria Wien | FC Villarreal | Group C | 0-1 | 2 - 4 points |
| 13/10/22 17:45 | 13/10/22 17:45 | Apollon Limassol FC | AZ Alkmaar | Group E | 1-0 | 2 - 4 points |
| 13/10/22 17:45 | 13/10/22 17:45 | Istanbul Basaksehir FK | Rigas Futbola Skola | Group A | 3-0 | 2 - 4 points |
| 13/10/22 17:45 | 13/10/22 17:45 | Fiorentina | Heart of Midlothian | Group A | 5-1 | 2 - 4 points |
| 13/10/22 20:00 | 13/10/22 20:00 | OGC Nice | 1. FC Slovacko | Group D | 1-2 | 2 - 4 points |
| 13/10/22 20:00 | 13/10/22 20:00 | Zalgiris Vilnius | Pyunik | Group H | 2-1 | 2 - 4 points |
| 13/10/22 20:00 | 13/10/22 20:00 | KF Ballkani Suhareka | Sivasspor | Group G | 1-2 | 2 - 4 points |
| 13/10/22 20:00 | 13/10/22 20:00 | Shamrock Rovers | Molde FK | Group F | 0-2 | 2 - 4 points |
| 13/10/22 20:00 | 13/10/22 20:00 | FC Vaduz | SK Dnipro-1 | Group E | 1-2 | 2 - 4 points |
| 13/10/22 20:00 | 13/10/22 20:00 | Hapoel Beer Sheva | Lech Poznan | Group C | 1-1 | 2 - 4 points |
| 13/10/22 20:00 | 13/10/22 20:00 | West Ham United | RSC Anderlecht | Group B | 2-1 | 2 - 4 points |
| 13/10/22 20:00 | 13/10/22 20:00 | FCSB Bukarest | Silkeborg IF | Group B | 0-5 | 2 - 4 points |