Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 21/10/21 15:30 | 21/10/21 15:30 | HJK Helsinki | Maccabi Tel Aviv | Group A | 0-5 | 2 - 4 points |
| 21/10/21 17:45 | 21/10/21 17:45 | Alashkert Erewan | Linzer ASK | Group A | 0-3 | 2 - 4 points |
| 21/10/21 17:45 | 21/10/21 17:45 | Anorthosis Famagusta | Flora Tallinn | Group B | 2-2 | 2 - 4 points |
| 21/10/21 17:45 | 21/10/21 17:45 | FK Bodö/Glimt | AS Roma | Group C | 6-1 | 2 - 4 points |
| 21/10/21 17:45 | 21/10/21 17:45 | Maccabi Haifa | Slavia Prag | Group E | 1-0 | 2 - 4 points |
| 21/10/21 17:45 | 21/10/21 17:45 | Feyenoord Rotterdam | 1. FC Union Berlin | Group E | 3-1 | 2 - 4 points |
| 21/10/21 17:45 | 21/10/21 17:45 | FC Copenhagen | PAOK Saloniki | Group F | 1-2 | 2 - 4 points |
| 21/10/21 17:45 | 21/10/21 17:45 | NS Mura | Stade Rennes | Group G | 1-2 | 2 - 4 points |
| 21/10/21 17:45 | 21/10/21 17:45 | Vitesse Arnheim | Tottenham Hotspur | Group G | 1-0 | 2 - 4 points |
| 21/10/21 17:45 | 21/10/21 17:45 | Qarabag | Qairat Almaty | Group H | 2-1 | 2 - 4 points |
| 21/10/21 20:00 | 21/10/21 20:00 | Partizan Belgrad | KAA Gent | Group B | 0-1 | 2 - 4 points |
| 21/10/21 20:00 | 21/10/21 20:00 | ZSKA Sofia | FC Zorya Lugansk | Group C | 0-1 | 2 - 4 points |
| 21/10/21 20:00 | 21/10/21 20:00 | CFR Cluj | AZ Alkmaar | Group D | 0-1 | 2 - 4 points |
| 21/10/21 20:00 | 21/10/21 20:00 | Jablonec | Randers | Group D | 2-2 | 2 - 4 points |
| 21/10/21 20:00 | 21/10/21 20:00 | SK Slovan Bratislava | Lincoln Red Imps FC | Group F | 2-0 | 2 - 4 points |
| 21/10/21 20:00 | 21/10/21 20:00 | FC Basel | Omonia Nicosia | Group H | 3-1 | 2 - 4 points |