Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 06/10/22 17:45 | 06/10/22 17:45 | 1. FC Slovacko | OGC Nice | Group D | 0-1 | 2 - 4 points |
| 06/10/22 17:45 | 06/10/22 17:45 | Pyunik | Zalgiris Vilnius | Group H | 2-0 | 2 - 4 points |
| 06/10/22 17:45 | 06/10/22 17:45 | Sivasspor | KF Ballkani Suhareka | Group G | 3-4 | 2 - 4 points |
| 06/10/22 17:45 | 06/10/22 17:45 | Molde FK | Shamrock Rovers | Group F | 3-0 | 2 - 4 points |
| 06/10/22 17:45 | 06/10/22 17:45 | Lech Poznan | Hapoel Beer Sheva | Group C | 0-0 | 2 - 4 points |
| 06/10/22 17:45 | 06/10/22 17:45 | SK Dnipro-1 | FC Vaduz | Group E | 2-2 | 2 - 4 points |
| 06/10/22 17:45 | 06/10/22 17:45 | RSC Anderlecht | West Ham United | Group B | 0-1 | 2 - 4 points |
| 06/10/22 17:45 | 06/10/22 17:45 | Silkeborg IF | FCSB Bukarest | Group B | 5-0 | 2 - 4 points |
| 06/10/22 20:00 | 06/10/22 20:00 | 1. FC Köln | Partizan Belgrad | Group D | 0-1 | 2 - 4 points |
| 06/10/22 20:00 | 06/10/22 20:00 | FC Basel | SK Slovan Bratislava | Group H | 0-2 | 2 - 4 points |
| 06/10/22 20:00 | 06/10/22 20:00 | Slavia Prag | CFR Cluj | Group G | 0-1 | 2 - 4 points |
| 06/10/22 20:00 | 06/10/22 20:00 | KAA Gent | Djurgardens IF | Group F | 0-1 | 2 - 4 points |
| 06/10/22 20:00 | 06/10/22 20:00 | FC Villarreal | FK Austria Wien | Group C | 5-0 | 2 - 4 points |
| 06/10/22 20:00 | 06/10/22 20:00 | AZ Alkmaar | Apollon Limassol FC | Group E | 3-2 | 2 - 4 points |
| 06/10/22 20:00 | 06/10/22 20:00 | Heart of Midlothian | Fiorentina | Group A | 0-3 | 2 - 4 points |
| 06/10/22 20:00 | 06/10/22 20:00 | Rigas Futbola Skola | Istanbul Basaksehir FK | Group A | 0-0 | 2 - 4 points |