Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 30/09/21 17:45 | 30/09/21 17:45 | Linzer ASK | Maccabi Tel Aviv | Group A | 1-1 | 2 - 4 points |
| 30/09/21 17:45 | 30/09/21 17:45 | Alashkert Erewan | HJK Helsinki | Group A | 2-4 | 2 - 4 points |
| 30/09/21 17:45 | 30/09/21 17:45 | Partizan Belgrad | Flora Tallinn | Group B | 2-0 | 2 - 4 points |
| 30/09/21 17:45 | 30/09/21 17:45 | KAA Gent | Anorthosis Famagusta | Group B | 2-0 | 2 - 4 points |
| 30/09/21 17:45 | 30/09/21 17:45 | ZSKA Sofia | FK Bodö/Glimt | Group C | 0-0 | 2 - 4 points |
| 30/09/21 17:45 | 30/09/21 17:45 | FC Zorya Lugansk | AS Roma | Group C | 0-3 | 2 - 4 points |
| 30/09/21 17:45 | 30/09/21 17:45 | CFR Cluj | Randers | Group D | 1-1 | 2 - 4 points |
| 30/09/21 17:45 | 30/09/21 17:45 | AZ Alkmaar | Jablonec | Group D | 1-0 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | Feyenoord Rotterdam | Slavia Prag | Group E | 2-1 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | 1. FC Union Berlin | Maccabi Haifa | Group E | 3-0 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | FC Copenhagen | Lincoln Red Imps FC | Group F | 3-1 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | PAOK Saloniki | SK Slovan Bratislava | Group F | 1-1 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | Vitesse Arnheim | Stade Rennes | Group G | 1-2 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | Tottenham Hotspur | NS Mura | Group G | 5-1 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | FC Basel | Qairat Almaty | Group H | 4-2 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | Omonia Nicosia | Qarabag | Group H | 1-4 | 2 - 4 points |