Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 15/09/22 17:45 | 15/09/22 17:45 | Zalgiris Vilnius | FC Basel | Group H | 0-1 | 2 - 4 points |
| 15/09/22 17:45 | 15/09/22 17:45 | Slavia Prag | KF Ballkani Suhareka | Group G | 3-2 | 2 - 4 points |
| 15/09/22 17:45 | 15/09/22 17:45 | Pyunik | SK Slovan Bratislava | Group H | 2-0 | 2 - 4 points |
| 15/09/22 17:45 | 15/09/22 17:45 | Djurgardens IF | Molde FK | Group F | 3-2 | 2 - 4 points |
| 15/09/22 17:45 | 15/09/22 17:45 | CFR Cluj | Sivasspor | Group G | 0-1 | 2 - 4 points |
| 15/09/22 17:45 | 15/09/22 17:45 | KAA Gent | Shamrock Rovers | Group F | 3-0 | 2 - 4 points |
| 15/09/22 17:45 | 15/09/22 17:45 | Apollon Limassol FC | SK Dnipro-1 | Group E | 1-3 | 2 - 4 points |
| 15/09/22 17:45 | 15/09/22 17:45 | AZ Alkmaar | FC Vaduz | Group E | 4-1 | 2 - 4 points |
| 15/09/22 20:00 | 15/09/22 20:00 | 1. FC Köln | 1. FC Slovacko | Group D | 4-2 | 2 - 4 points |
| 15/09/22 20:00 | 15/09/22 20:00 | Partizan Belgrad | OGC Nice | Group D | 1-1 | 2 - 4 points |
| 15/09/22 20:00 | 15/09/22 20:00 | Lech Poznan | FK Austria Wien | Group C | 4-1 | 2 - 4 points |
| 15/09/22 20:00 | 15/09/22 20:00 | Hapoel Beer Sheva | FC Villarreal | Group C | 1-2 | 2 - 4 points |
| 15/09/22 20:00 | 15/09/22 20:00 | FCSB Bukarest | RSC Anderlecht | Group B | 0-0 | 2 - 4 points |
| 15/09/22 20:00 | 15/09/22 20:00 | Rigas Futbola Skola | Heart of Midlothian | Group A | 0-2 | 2 - 4 points |
| 15/09/22 20:00 | 15/09/22 20:00 | Silkeborg IF | West Ham United | Group B | 2-3 | 2 - 4 points |
| 15/09/22 20:00 | 15/09/22 20:00 | Istanbul Basaksehir FK | Fiorentina | Group A | 3-0 | 2 - 4 points |