Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 14/04/22 17:45 | 14/04/22 17:45 | PSV Eindhoven | Leicester City | 1-2 | 2 - 4 points |
| 14/04/22 20:00 | 14/04/22 20:00 | PAOK Saloniki | Olympique Marseille | 0-1 | 2 - 4 points |
| 14/04/22 20:00 | 14/04/22 20:00 | AS Roma | FK Bodö/Glimt | 4-0 | 2 - 4 points |
| 14/04/22 20:00 | 14/04/22 20:00 | Slavia Prag | Feyenoord Rotterdam | 1-3 | 2 - 4 points |