Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 07/04/22 17:45 | 07/04/22 17:45 | Feyenoord Rotterdam | Slavia Prag | 3-3 | 2 - 4 points |
| 07/04/22 20:00 | 07/04/22 20:00 | Olympique Marseille | PAOK Saloniki | 2-1 | 2 - 4 points |
| 07/04/22 20:00 | 07/04/22 20:00 | FK Bodö/Glimt | AS Roma | 2-1 | 2 - 4 points |
| 07/04/22 20:00 | 07/04/22 20:00 | Leicester City | PSV Eindhoven | 0-0 | 2 - 4 points |