Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/03/22 17:45 | 17/03/22 17:45 | AZ Alkmaar | FK Bodö/Glimt | 2-2a.e.t | 2 - 4 points |
| 17/03/22 17:45 | 17/03/22 17:45 | FC Basel | Olympique Marseille | 1-2 | 2 - 4 points |
| 17/03/22 17:45 | 17/03/22 17:45 | Stade Rennes | Leicester City | 2-1 | 2 - 4 points |
| 17/03/22 17:45 | 17/03/22 17:45 | FC Copenhagen | PSV Eindhoven | 0-4 | 2 - 4 points |
| 17/03/22 20:00 | 17/03/22 20:00 | Linzer ASK | Slavia Prag | 4-3 | 2 - 4 points |
| 17/03/22 20:00 | 17/03/22 20:00 | AS Roma | Vitesse Arnheim | 1-1 | 2 - 4 points |
| 17/03/22 20:00 | 17/03/22 20:00 | KAA Gent | PAOK Saloniki | 1-2 | 2 - 4 points |
| 17/03/22 20:00 | 17/03/22 20:00 | Feyenoord Rotterdam | Partizan Belgrad | 3-1 | 2 - 4 points |