Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 14/09/21 15:30 | 14/09/21 15:30 | Maccabi Haifa | Feyenoord Rotterdam | Group E | 0-0 | 2 - 4 points |
| 14/09/21 15:30 | 14/09/21 15:30 | Maccabi Tel Aviv | Alashkert Erewan | Group A | 4-1 | 2 - 4 points |
| 16/09/21 15:30 | 16/09/21 15:30 | Qairat Almaty | Omonia Nicosia | Group H | 0-0 | 2 - 4 points |
| 16/09/21 17:45 | 16/09/21 17:45 | Slavia Prag | 1. FC Union Berlin | Group E | 3-1 | 2 - 4 points |
| 16/09/21 17:45 | 16/09/21 17:45 | SK Slovan Bratislava | FC Copenhagen | Group F | 1-3 | 2 - 4 points |
| 16/09/21 17:45 | 16/09/21 17:45 | Lincoln Red Imps FC | PAOK Saloniki | Group F | 0-2 | 2 - 4 points |
| 16/09/21 17:45 | 16/09/21 17:45 | Stade Rennes | Tottenham Hotspur | Group G | 2-2 | 2 - 4 points |
| 16/09/21 17:45 | 16/09/21 17:45 | NS Mura | Vitesse Arnheim | Group G | 0-2 | 2 - 4 points |
| 16/09/21 17:45 | 16/09/21 17:45 | Qarabag | FC Basel | Group H | 0-0 | 2 - 4 points |
| 16/09/21 17:45 | 16/09/21 17:45 | HJK Helsinki | Linzer ASK | Group A | 0-2 | 2 - 4 points |
| 16/09/21 17:45 | 16/09/21 17:45 | Flora Tallinn | KAA Gent | Group B | 0-1 | 2 - 4 points |
| 16/09/21 20:00 | 16/09/21 20:00 | Anorthosis Famagusta | Partizan Belgrad | Group B | 0-2 | 2 - 4 points |
| 16/09/21 20:00 | 16/09/21 20:00 | AS Roma | ZSKA Sofia | Group C | 5-1 | 2 - 4 points |
| 16/09/21 20:00 | 16/09/21 20:00 | FK Bodö/Glimt | FC Zorya Lugansk | Group C | 3-1 | 2 - 4 points |
| 16/09/21 20:00 | 16/09/21 20:00 | Jablonec | CFR Cluj | Group D | 1-0 | 2 - 4 points |
| 16/09/21 20:00 | 16/09/21 20:00 | Randers | AZ Alkmaar | Group D | 2-2 | 2 - 4 points |