Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 08/09/22 17:45 | 08/09/22 17:45 | 1. FC Slovacko | Partizan Belgrad | Group D | 3-3 | 2 - 4 points |
| 08/09/22 17:45 | 08/09/22 17:45 | KF Ballkani Suhareka | CFR Cluj | Group G | 1-1 | 2 - 4 points |
| 08/09/22 17:45 | 08/09/22 17:45 | FK Austria Wien | Hapoel Beer Sheva | Group C | 0-0 | 2 - 4 points |
| 08/09/22 17:45 | 08/09/22 17:45 | FC Villarreal | Lech Poznan | Group C | 4-3 | 2 - 4 points |
| 08/09/22 17:45 | 08/09/22 17:45 | RSC Anderlecht | Silkeborg IF | Group B | 1-0 | 2 - 4 points |
| 08/09/22 17:45 | 08/09/22 17:45 | Heart of Midlothian | Istanbul Basaksehir FK | Group A | 0-4 | 2 - 4 points |
| 08/09/22 17:45 | 08/09/22 17:45 | Fiorentina | Rigas Futbola Skola | Group A | 1-1 | 2 - 4 points |
| 08/09/22 18:40 | 08/09/22 18:40 | OGC Nice | 1. FC Köln | Group D | 1-1 | 2 - 4 points |
| 08/09/22 20:00 | 08/09/22 20:00 | SK Slovan Bratislava | Zalgiris Vilnius | Group H | 0-0 | 2 - 4 points |
| 08/09/22 20:00 | 08/09/22 20:00 | FC Basel | Pyunik | Group H | 3-1 | 2 - 4 points |
| 08/09/22 20:00 | 08/09/22 20:00 | Sivasspor | Slavia Prag | Group G | 1-1 | 2 - 4 points |
| 08/09/22 20:00 | 08/09/22 20:00 | Shamrock Rovers | Djurgardens IF | Group F | 0-0 | 2 - 4 points |
| 08/09/22 20:00 | 08/09/22 20:00 | Molde FK | KAA Gent | Group F | 0-0 | 2 - 4 points |
| 08/09/22 20:00 | 08/09/22 20:00 | FC Vaduz | Apollon Limassol FC | Group E | 0-0 | 2 - 4 points |
| 08/09/22 20:00 | 08/09/22 20:00 | SK Dnipro-1 | AZ Alkmaar | Group E | 0-1 | 2 - 4 points |
| 08/09/22 20:00 | 08/09/22 20:00 | West Ham United | FCSB Bukarest | Group B | 3-1 | 2 - 4 points |