| Date | Home | Away | Result |
|---|---|---|---|
| 14/04/22 17:45 | PSV Eindhoven | Leicester City | 1-2 |
| 14/04/22 20:00 | PAOK Saloniki | Olympique Marseille | 0-1 |
| 14/04/22 20:00 | AS Roma | FK Bodö/Glimt | 4-0 |
| 14/04/22 20:00 | Slavia Prag | Feyenoord Rotterdam | 1-3 |
| Date | Home | Away | Result |
|---|---|---|---|
| 14/04/22 17:45 | PSV Eindhoven | Leicester City | 1-2 |
| 14/04/22 20:00 | PAOK Saloniki | Olympique Marseille | 0-1 |
| 14/04/22 20:00 | AS Roma | FK Bodö/Glimt | 4-0 |
| 14/04/22 20:00 | Slavia Prag | Feyenoord Rotterdam | 1-3 |