Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 19/10/21 17:45 | 19/10/21 17:45 | Club Brugge | Manchester City | Group A | 1-5 | 2 - 4 points |
| 19/10/21 17:45 | 19/10/21 17:45 | Besiktas Istanbul | Sporting Lisbon | Group C | 1-4 | 2 - 4 points |
| 19/10/21 20:00 | 19/10/21 20:00 | Schachtjor Donezk | Real Madrid | Group D | 0-5 | 2 - 4 points |
| 19/10/21 20:00 | 19/10/21 20:00 | Inter Milan | Sheriff Tiraspol | Group D | 3-1 | 2 - 4 points |
| 19/10/21 20:00 | 19/10/21 20:00 | FC Porto | AC Milan | Group B | 1-0 | 2 - 4 points |
| 19/10/21 20:00 | 19/10/21 20:00 | Atletico Madrid | Liverpool FC | Group B | 2-3 | 2 - 4 points |
| 19/10/21 20:00 | 19/10/21 20:00 | Paris St. Germain | RB Leipzig | Group A | 3-2 | 2 - 4 points |
| 19/10/21 20:00 | 19/10/21 20:00 | Ajax Amsterdam | Borussia Dortmund | Group C | 4-0 | 2 - 4 points |
| 20/10/21 17:45 | 20/10/21 17:45 | FC Red Bull Salzburg | VfL Wolfsburg | Group G | 3-1 | 2 - 4 points |
| 20/10/21 17:45 | 20/10/21 17:45 | FC Barcelona | Dynamo Kiew | Group E | 1-0 | 2 - 4 points |
| 20/10/21 20:00 | 20/10/21 20:00 | Chelsea FC | Malmö FF | Group H | 4-0 | 2 - 4 points |
| 20/10/21 20:00 | 20/10/21 20:00 | Zenit St. Petersburg | Juventus Turin | Group H | 0-1 | 2 - 4 points |
| 20/10/21 20:00 | 20/10/21 20:00 | OSC Lille | FC Sevilla | Group G | 0-0 | 2 - 4 points |
| 20/10/21 20:00 | 20/10/21 20:00 | Benfica Lisbon | FC Bayern Munich | Group E | 0-4 | 2 - 4 points |
| 20/10/21 20:00 | 20/10/21 20:00 | Young Boys Bern | FC Villarreal | Group F | 1-4 | 2 - 4 points |
| 20/10/21 20:00 | 20/10/21 20:00 | Manchester United | Atalanta Bergamo | Group F | 3-2 | 2 - 4 points |