Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 06/09/22 17:45 | 06/09/22 17:45 | Borussia Dortmund | FC Copenhagen | Group G | 3-0 | 2 - 4 points |
| 06/09/22 17:45 | 06/09/22 17:45 | Dinamo Zagreb | Chelsea FC | Group E | 1-0 | 2 - 4 points |
| 06/09/22 20:00 | 06/09/22 20:00 | RB Leipzig | Schachtjor Donezk | Group F | 1-4 | 2 - 4 points |
| 06/09/22 20:00 | 06/09/22 20:00 | Celtic Glasgow | Real Madrid | Group F | 0-3 | 2 - 4 points |
| 06/09/22 20:00 | 06/09/22 20:00 | FC Sevilla | Manchester City | Group G | 0-4 | 2 - 4 points |
| 06/09/22 20:00 | 06/09/22 20:00 | Paris St. Germain | Juventus Turin | Group H | 2-1 | 2 - 4 points |
| 06/09/22 20:00 | 06/09/22 20:00 | Benfica Lisbon | Maccabi Haifa | Group H | 2-0 | 2 - 4 points |
| 06/09/22 20:00 | 06/09/22 20:00 | FC Red Bull Salzburg | AC Milan | Group E | 1-1 | 2 - 4 points |
| 07/09/22 17:45 | 07/09/22 17:45 | Ajax Amsterdam | Glasgow Rangers | Group A | 4-0 | 2 - 4 points |
| 07/09/22 17:45 | 07/09/22 17:45 | Eintracht Frankfurt | Sporting Lisbon | Group D | 0-3 | 2 - 4 points |
| 07/09/22 20:00 | 07/09/22 20:00 | SSC Napoli | Liverpool FC | Group A | 4-1 | 2 - 4 points |
| 07/09/22 20:00 | 07/09/22 20:00 | Club Brugge | Bayer 04 Leverkusen | Group B | 1-0 | 2 - 4 points |
| 07/09/22 20:00 | 07/09/22 20:00 | Atletico Madrid | FC Porto | Group B | 2-1 | 2 - 4 points |
| 07/09/22 20:00 | 07/09/22 20:00 | Inter Milan | FC Bayern Munich | Group C | 0-2 | 2 - 4 points |
| 07/09/22 20:00 | 07/09/22 20:00 | FC Barcelona | Viktoria Plzen | Group C | 5-1 | 2 - 4 points |
| 07/09/22 20:00 | 07/09/22 20:00 | Tottenham Hotspur | Olympique Marseille | Group D | 2-0 | 2 - 4 points |