Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 16/10/21 12:30 | 16/10/21 12:30 | Watford FC | Liverpool FC | 0-5 | 2 - 5 points |
| 16/10/21 15:00 | 16/10/21 15:00 | Aston Villa | Wolverhampton Wanderers | 2-3 | 2 - 5 points |
| 16/10/21 15:00 | 16/10/21 15:00 | Leicester City | Manchester United | 4-2 | 2 - 5 points |
| 16/10/21 15:00 | 16/10/21 15:00 | Manchester City | Burnley FC | 2-0 | 2 - 5 points |
| 16/10/21 15:00 | 16/10/21 15:00 | Norwich City | Brighton and Hove Albion | 0-0 | 2 - 5 points |
| 16/10/21 15:00 | 16/10/21 15:00 | Southampton FC | Leeds United | 1-0 | 2 - 5 points |
| 16/10/21 17:30 | 16/10/21 17:30 | Brentford FC | Chelsea FC | 0-1 | 2 - 5 points |
| 17/10/21 14:00 | 17/10/21 14:00 | Everton FC | West Ham United | 0-1 | 2 - 5 points |
| 17/10/21 16:30 | 17/10/21 16:30 | Newcastle United | Tottenham Hotspur | 2-3 | 2 - 5 points |
| 18/10/21 20:00 | 18/10/21 20:00 | Arsenal FC | Crystal Palace | 2-2 | 2 - 5 points |