Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 21/08/21 12:30 | 21/08/21 12:30 | Liverpool FC | Burnley FC | 2-0 | 2 - 5 points |
| 21/08/21 15:00 | 21/08/21 15:00 | Aston Villa | Newcastle United | 2-0 | 2 - 5 points |
| 21/08/21 15:00 | 21/08/21 15:00 | Crystal Palace | Brentford FC | 0-0 | 2 - 5 points |
| 21/08/21 15:00 | 21/08/21 15:00 | Manchester City | Norwich City | 5-0 | 2 - 5 points |
| 21/08/21 15:00 | 21/08/21 15:00 | Leeds United | Everton FC | 2-2 | 2 - 5 points |
| 21/08/21 17:30 | 21/08/21 17:30 | Brighton and Hove Albion | Watford FC | 2-0 | 2 - 5 points |
| 22/08/21 14:00 | 22/08/21 14:00 | Southampton FC | Manchester United | 1-1 | 2 - 5 points |
| 22/08/21 14:00 | 22/08/21 14:00 | Wolverhampton Wanderers | Tottenham Hotspur | 0-1 | 2 - 5 points |
| 22/08/21 16:30 | 22/08/21 16:30 | Arsenal FC | Chelsea FC | 0-2 | 2 - 5 points |
| 23/08/21 20:00 | 23/08/21 20:00 | West Ham United | Leicester City | 4-1 | 2 - 5 points |