Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 03/09/21 18:00 | 03/09/21 18:00 | 1. FC Saarbrücken | SV Wehen Wiesbaden | 3-4 | 5 - 7 points |
| 04/09/21 13:00 | 04/09/21 13:00 | SC Verl | Viktoria 1889 Berlin | 3-3 | 5 - 7 points |
| 04/09/21 13:00 | 04/09/21 13:00 | SV Waldhof Mannheim | Türkgücü München | 3-0 | 5 - 7 points |
| 04/09/21 13:00 | 04/09/21 13:00 | MSV Duisburg | FC Würzburger Kickers | 2-0 | 5 - 7 points |
| 04/09/21 13:00 | 04/09/21 13:00 | TSV 1860 Munich | SV Meppen | 1-1 | 5 - 7 points |
| 04/09/21 17:00 | 04/09/21 17:00 | 1. FC Magdeburg | 1. FC Kaiserslautern | 1-0 | 5 - 7 points |
| 05/09/21 13:00 | 05/09/21 13:00 | TSV Havelse | Borussia Dortmund II | 0-1 | 5 - 7 points |
| 06/09/21 18:00 | 06/09/21 18:00 | VfL Osnabrück | FC Viktoria Köln | 3-0 | 5 - 7 points |
| 15/09/21 18:00 | 15/09/21 18:00 | FSV Zwickau | Hallescher FC | 2-2 | 5 - 7 points |
| 22/09/21 18:00 | 22/09/21 18:00 | SC Freiburg II | Eintracht Braunschweig | 0-1 | 5 - 7 points |