| Date | Home | Away | Result |
|---|---|---|---|
| 09/12/25 15:30 | Kairat Almaty | Olympiakos Piräus | --- |
| 09/12/25 17:45 | FC Bayern Munich | Sporting Lisbon | --- |
| 09/12/25 20:00 | AS Monaco | Galatasaray Istanbul | --- |
| 09/12/25 20:00 | FC Barcelona | Eintracht Frankfurt | --- |
| 09/12/25 20:00 | PSV Eindhoven | Atletico Madrid | --- |
| 09/12/25 20:00 | Atalanta Bergamo | Chelsea FC | --- |
| 09/12/25 20:00 | Tottenham Hotspur | Slavia Prag | --- |
| 09/12/25 20:00 | Royale Union Saint-Gilloise | Olympique Marseille | --- |
| 09/12/25 20:00 | Inter Milan | Liverpool FC | --- |
| 10/12/25 17:45 | FC Villarreal | FC Copenhagen | --- |
| 10/12/25 17:45 | Qarabag | Ajax Amsterdam | --- |
| 10/12/25 20:00 | Athletic Bilbao | Paris St. Germain | --- |
| 10/12/25 20:00 | Bayer 04 Leverkusen | Newcastle United | --- |
| 10/12/25 20:00 | Borussia Dortmund | FK Bodö/Glimt | --- |
| 10/12/25 20:00 | Club Brugge | Arsenal FC | --- |
| 10/12/25 20:00 | Juventus Turin | Pafos FC | --- |
| 10/12/25 20:00 | Real Madrid | Manchester City | --- |
| 10/12/25 20:00 | Benfica Lisbon | SSC Napoli | --- |