| Date | Home | Away | Result |
|---|---|---|---|
| 25/11/25 17:45 | Ajax Amsterdam | Benfica Lisbon | --- |
| 25/11/25 17:45 | Galatasaray Istanbul | Royale Union Saint-Gilloise | --- |
| 25/11/25 20:00 | FK Bodö/Glimt | Juventus Turin | --- |
| 25/11/25 20:00 | Borussia Dortmund | FC Villarreal | --- |
| 25/11/25 20:00 | SSC Napoli | Qarabag | --- |
| 25/11/25 20:00 | Slavia Prag | Athletic Bilbao | --- |
| 25/11/25 20:00 | Manchester City | Bayer 04 Leverkusen | --- |
| 25/11/25 20:00 | Olympique Marseille | Newcastle United | --- |
| 25/11/25 20:00 | Chelsea FC | FC Barcelona | --- |
| 26/11/25 17:45 | Pafos FC | AS Monaco | --- |
| 26/11/25 17:45 | FC Copenhagen | Kairat Almaty | --- |
| 26/11/25 20:00 | Arsenal FC | FC Bayern Munich | --- |
| 26/11/25 20:00 | Liverpool FC | PSV Eindhoven | --- |
| 26/11/25 20:00 | Sporting Lisbon | Club Brugge | --- |
| 26/11/25 20:00 | Eintracht Frankfurt | Atalanta Bergamo | --- |
| 26/11/25 20:00 | Paris St. Germain | Tottenham Hotspur | --- |
| 26/11/25 20:00 | Atletico Madrid | Inter Milan | --- |
| 26/11/25 20:00 | Olympiakos Piräus | Real Madrid | --- |