| Date | Home | Away | Result |
|---|---|---|---|
| 04/11/25 17:45 | Slavia Prag | Arsenal FC | --- |
| 04/11/25 17:45 | SSC Napoli | Eintracht Frankfurt | --- |
| 04/11/25 20:00 | Olympiakos Piräus | PSV Eindhoven | --- |
| 04/11/25 20:00 | Liverpool FC | Real Madrid | --- |
| 04/11/25 20:00 | Juventus Turin | Sporting Lisbon | --- |
| 04/11/25 20:00 | Paris St. Germain | FC Bayern Munich | --- |
| 04/11/25 20:00 | Atletico Madrid | Royale Union Saint-Gilloise | --- |
| 04/11/25 20:00 | Tottenham Hotspur | FC Copenhagen | --- |
| 04/11/25 20:00 | FK Bodö/Glimt | AS Monaco | --- |
| 05/11/25 17:45 | Qarabag | Chelsea FC | --- |
| 05/11/25 17:45 | Pafos FC | FC Villarreal | --- |
| 05/11/25 20:00 | Manchester City | Borussia Dortmund | --- |
| 05/11/25 20:00 | Benfica Lisbon | Bayer 04 Leverkusen | --- |
| 05/11/25 20:00 | Olympique Marseille | Atalanta Bergamo | --- |
| 05/11/25 20:00 | Inter Milan | Kairat Almaty | --- |
| 05/11/25 20:00 | Club Brugge | FC Barcelona | --- |
| 05/11/25 20:00 | Ajax Amsterdam | Galatasaray Istanbul | --- |
| 05/11/25 20:00 | Newcastle United | Athletic Bilbao | --- |