Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 02/04/22 14:00 | 02/04/22 14:00 | Castres Olympique | Stade Toulousain | 19-13 | 6 - 10 - 3 |
| 02/04/22 16:00 | 02/04/22 16:00 | Lyon OU | RC Toulon | 10-43 | 3 - 10 - 9 |
| 02/04/22 16:00 | 02/04/22 16:00 | Biarritz | Section Paloise | 19-42 | 4 - 10 - 4 |
| 02/04/22 16:00 | 02/04/22 16:00 | USA Perpignan | Montpellier Hérault RC | 13-23 | 5 - 10 - 4 |
| 02/04/22 16:00 | 02/04/22 16:00 | ASM Clermont Auvergne | CA Brive | 41-10 | 3 - 10 - 10 |
| 02/04/22 20:05 | 02/04/22 20:05 | Union Bordeaux Bègles | Atlantique Stade Rochelais | 15-16 | 3 - 10 - 8 |
| 03/04/22 20:05 | 03/04/22 20:05 | Racing Métro 92 | Stade Français | 53-20 | 3 - 10 - 10 |