Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| 2.BL | 24/09/21 17:30 | 24/09/21 16:30 | 1. FC Heidenheim 1846 | SV Darmstadt 98 | 2-1 | 2 - 4 points |
| 2.BL | 24/09/21 17:30 | 24/09/21 16:30 | Jahn Regensburg | Erzgebirge Aue | 3-2 | 2 - 4 points |
| GER1 | 24/09/21 19:30 | 24/09/21 18:30 | SpVgg Greuther Fürth | FC Bayern Munich | 1-3 | 2 - 4 points |
| RLNO | 25/09/21 12:00 | 25/09/21 11:00 | Energie Cottbus | FC Eilenburg | 9-0 | 2 - 4 points |
| 2.BL | 25/09/21 12:30 | 25/09/21 11:30 | Karlsruher SC | FC St. Pauli | 1-3 | 2 - 4 points |
| 2.BL | 25/09/21 12:30 | 25/09/21 11:30 | SC Paderborn 07 | Holstein Kiel | 1-2 | 2 - 4 points |
| 2.BL | 25/09/21 12:30 | 25/09/21 11:30 | FC Ingolstadt | Fortuna Düsseldorf | 1-2 | 2 - 4 points |
| GER1 | 25/09/21 14:30 | 25/09/21 13:30 | Eintracht Frankfurt | 1. FC Köln | 1-1 | 2 - 4 points |
| GER1 | 25/09/21 14:30 | 25/09/21 13:30 | RB Leipzig | Hertha BSC | 6-0 | 2 - 4 points |
| GER1 | 25/09/21 14:30 | 25/09/21 13:30 | 1899 Hoffenheim | VfL Wolfsburg | 3-1 | 2 - 4 points |
| GER1 | 25/09/21 14:30 | 25/09/21 13:30 | 1. FC Union Berlin | Arminia Bielefeld | 1-0 | 2 - 4 points |
| GER1 | 25/09/21 14:30 | 25/09/21 13:30 | Bayer 04 Leverkusen | FSV Mainz 05 | 1-0 | 2 - 4 points |
| GER1 | 25/09/21 17:30 | 25/09/21 16:30 | Bor. Mönchengladbach | Borussia Dortmund | 1-0 | 2 - 4 points |
| 2.BL | 25/09/21 19:30 | 25/09/21 18:30 | FC Hansa Rostock | FC Schalke 04 | 0-2 | 2 - 4 points |
| 2.BL | 26/09/21 12:30 | 26/09/21 11:30 | Hannover 96 | SV Sandhausen | 1-2 | 2 - 4 points |
| 2.BL | 26/09/21 12:30 | 26/09/21 11:30 | Dynamo Dresden | Werder Bremen | 3-0 | 2 - 4 points |
| 2.BL | 26/09/21 12:30 | 26/09/21 11:30 | Hamburger SV | 1. FC Nürnberg | 2-2 | 2 - 4 points |
| GER1 | 26/09/21 14:30 | 26/09/21 13:30 | VfL Bochum | VfB Stuttgart | 0-0 | 2 - 4 points |
| GER1 | 26/09/21 16:30 | 26/09/21 15:30 | SC Freiburg | FC Augsburg | 3-0 | 2 - 4 points |