Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| 2.BL | 26/11/21 17:30 | 26/11/21 16:30 | Jahn Regensburg | Dynamo Dresden | 3-1 | 2 - 4 points |
| 2.BL | 26/11/21 17:30 | 26/11/21 16:30 | Fortuna Düsseldorf | 1. FC Heidenheim 1846 | 0-1 | 2 - 4 points |
| GER1 | 26/11/21 19:30 | 26/11/21 18:30 | VfB Stuttgart | FSV Mainz 05 | 2-1 | 2 - 4 points |
| 2.BL | 27/11/21 12:30 | 27/11/21 11:30 | Karlsruher SC | Hannover 96 | 4-0 | 2 - 4 points |
| 2.BL | 27/11/21 12:30 | 27/11/21 11:30 | Erzgebirge Aue | SV Darmstadt 98 | 1-2 | 2 - 4 points |
| 2.BL | 27/11/21 12:30 | 27/11/21 11:30 | FC Schalke 04 | SV Sandhausen | 5-2 | 2 - 4 points |
| RLNO | 27/11/21 13:05 | 27/11/21 12:05 | BSG Chemie Leipzig | Energie Cottbus | 1-2 | 2 - 4 points |
| GER1 | 27/11/21 14:30 | 27/11/21 13:30 | 1. FC Köln | Bor. Mönchengladbach | 4-1 | 2 - 4 points |
| GER1 | 27/11/21 14:30 | 27/11/21 13:30 | Hertha BSC | FC Augsburg | 1-1 | 2 - 4 points |
| GER1 | 27/11/21 14:30 | 27/11/21 13:30 | VfL Wolfsburg | Borussia Dortmund | 1-3 | 2 - 4 points |
| GER1 | 27/11/21 14:30 | 27/11/21 13:30 | SpVgg Greuther Fürth | 1899 Hoffenheim | 3-6 | 2 - 4 points |
| GER1 | 27/11/21 14:30 | 27/11/21 13:30 | VfL Bochum | SC Freiburg | 2-1 | 2 - 4 points |
| GER1 | 27/11/21 17:30 | 27/11/21 16:30 | FC Bayern Munich | Arminia Bielefeld | 1-0 | 2 - 4 points |
| 2.BL | 27/11/21 19:30 | 27/11/21 18:30 | Holstein Kiel | Werder Bremen | 2-1 | 2 - 4 points |
| 2.BL | 28/11/21 12:30 | 28/11/21 11:30 | SC Paderborn 07 | FC Hansa Rostock | 1-1 | 2 - 4 points |
| 2.BL | 28/11/21 12:30 | 28/11/21 11:30 | 1. FC Nürnberg | FC St. Pauli | 2-3 | 2 - 4 points |
| 2.BL | 28/11/21 12:30 | 28/11/21 11:30 | Hamburger SV | FC Ingolstadt | 3-0 | 2 - 4 points |
| GER1 | 28/11/21 14:30 | 28/11/21 13:30 | Eintracht Frankfurt | 1. FC Union Berlin | 2-1 | 2 - 4 points |
| GER1 | 28/11/21 16:30 | 28/11/21 15:30 | RB Leipzig | Bayer 04 Leverkusen | 1-3 | 2 - 4 points |