Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| 2.BL | 22/10/21 17:30 | 22/10/21 16:30 | Erzgebirge Aue | FC Ingolstadt | 1-0 | 2 - 4 points |
| 2.BL | 22/10/21 17:30 | 22/10/21 16:30 | SC Paderborn 07 | Hamburger SV | 1-2 | 2 - 4 points |
| GER1 | 22/10/21 19:30 | 22/10/21 18:30 | FSV Mainz 05 | FC Augsburg | 4-1 | 2 - 4 points |
| 2.BL | 23/10/21 12:30 | 23/10/21 11:30 | 1. FC Nürnberg | 1. FC Heidenheim 1846 | 4-0 | 2 - 4 points |
| 2.BL | 23/10/21 12:30 | 23/10/21 11:30 | Holstein Kiel | SV Darmstadt 98 | 1-1 | 2 - 4 points |
| 2.BL | 23/10/21 12:30 | 23/10/21 11:30 | Fortuna Düsseldorf | Karlsruher SC | 3-1 | 2 - 4 points |
| GER1 | 23/10/21 14:30 | 23/10/21 13:30 | RB Leipzig | SpVgg Greuther Fürth | 4-1 | 2 - 4 points |
| GER1 | 23/10/21 14:30 | 23/10/21 13:30 | FC Bayern Munich | 1899 Hoffenheim | 4-0 | 2 - 4 points |
| GER1 | 23/10/21 14:30 | 23/10/21 13:30 | Arminia Bielefeld | Borussia Dortmund | 1-3 | 2 - 4 points |
| GER1 | 23/10/21 14:30 | 23/10/21 13:30 | VfL Wolfsburg | SC Freiburg | 0-2 | 2 - 4 points |
| GER1 | 23/10/21 17:30 | 23/10/21 16:30 | Hertha BSC | Bor. Mönchengladbach | 1-0 | 2 - 4 points |
| 2.BL | 23/10/21 19:30 | 23/10/21 18:30 | FC Schalke 04 | Dynamo Dresden | 3-0 | 2 - 4 points |
| RLNO | 24/10/21 12:00 | 24/10/21 11:00 | Tasmania Berlin | Energie Cottbus | 2-1 | 2 - 4 points |
| 2.BL | 24/10/21 12:30 | 24/10/21 11:30 | FC St. Pauli | FC Hansa Rostock | 4-0 | 2 - 4 points |
| 2.BL | 24/10/21 12:30 | 24/10/21 11:30 | Jahn Regensburg | Hannover 96 | 3-1 | 2 - 4 points |
| 2.BL | 24/10/21 12:30 | 24/10/21 11:30 | SV Sandhausen | Werder Bremen | 2-2 | 2 - 4 points |
| GER1 | 24/10/21 14:30 | 24/10/21 13:30 | 1. FC Köln | Bayer 04 Leverkusen | 2-2 | 2 - 4 points |
| GER1 | 24/10/21 16:30 | 24/10/21 15:30 | VfB Stuttgart | 1. FC Union Berlin | 1-1 | 2 - 4 points |
| GER1 | 24/10/21 18:30 | 24/10/21 17:30 | VfL Bochum | Eintracht Frankfurt | 2-0 | 2 - 4 points |