Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| I.Div | 10/09/21 14:00 | 10/09/21 14:00 | Chrobry Glogow | Skra Czestochowa | 0-1 | 3 - 5 points |
| RLB | 10/09/21 16:15 | 10/09/21 16:15 | FC Pipinsried | 1. FC Schweinfurt 05 | 2-2 | 3 - 5 points |
| RLW | 10/09/21 17:30 | 10/09/21 17:30 | SV Rödinghausen | FC Schalke 04 II | 1-0 | 3 - 5 points |
| 3BL | 10/09/21 18:00 | 10/09/21 18:00 | SV Meppen | SC Freiburg II | 0-1 | 3 - 5 points |
| RLW | 10/09/21 18:00 | 10/09/21 18:00 | Alemannia Aachen | SC Wiedenbrück | 0-1 | 3 - 5 points |
| RLSW | 10/09/21 18:00 | 10/09/21 18:00 | Kickers Offenbach | TSG 1899 Hoffenheim II | 1-0 | 3 - 5 points |
| RLSW | 10/09/21 18:00 | 10/09/21 18:00 | FC 08 Homburg | FC-Astoria Walldorf | 3-2 | 3 - 5 points |
| RLSW | 10/09/21 18:00 | 10/09/21 18:00 | FSV Frankfurt | FSV Mainz 05 II | 1-2 | 3 - 5 points |
| RLNO | 10/09/21 18:00 | 10/09/21 18:00 | VSG Altglienicke | FC Eilenburg | 6-0 | 3 - 5 points |
| RLNO | 10/09/21 18:00 | 10/09/21 18:00 | FSV Optik Rathenow | Hertha BSC II | 2-2 | 3 - 5 points |
| RLB | 10/09/21 18:00 | 10/09/21 18:00 | FV Illertissen | 1. FC Nürnberg II | 2-4 | 3 - 5 points |
| RLB | 10/09/21 18:00 | 10/09/21 18:00 | SV Heimstetten | TSV Aubstadt | 1-4 | 3 - 5 points |
| RLB | 10/09/21 18:00 | 10/09/21 18:00 | FC Bayern Munich II | Viktoria Aschaffenburg | 2-2 | 3 - 5 points |
| GER-W | 10/09/21 18:15 | 10/09/21 18:15 | Bayer 04 Leverkusen | 1. FFC Turbine Potsdam | 2-0 | 3 - 5 points |
| RLW | 10/09/21 18:30 | 10/09/21 18:30 | 1. FC Köln II | Bonner SC | 3-2 | 3 - 5 points |
| RLW | 10/09/21 18:30 | 10/09/21 18:30 | Rot-Weiss Essen | VfB Homberg | 3-0 | 3 - 5 points |
| RLW | 10/09/21 18:30 | 10/09/21 18:30 | Rot-Weiss Ahlen | Preußen Münster | 1-1 | 3 - 5 points |
| RLB | 10/09/21 18:30 | 10/09/21 18:30 | FC Memmingen | TSV Buchbach | 0-1 | 3 - 5 points |
| SerB | 10/09/21 19:30 | 10/09/21 19:30 | Benevento Calcio | US Lecce | 0-0 | 3 - 5 points |
| I.Div | 10/09/21 19:30 | 10/09/21 19:30 | Widzew Lodz | GKS Katowice | 3-1 | 3 - 5 points |
| Pro | 10/09/21 19:45 | 10/09/21 19:45 | Club Brugge | KV Oostende | 3-0 | 3 - 5 points |
| L1 | 10/09/21 20:00 | 10/09/21 20:00 | FC Lorient | OSC Lille | 2-1 | 3 - 5 points |
| ESP2 | 10/09/21 20:00 | 10/09/21 20:00 | Sporting Gijon | CD Leganes | 2-1 | 3 - 5 points |
| Champ | 10/09/21 20:00 | 10/09/21 20:00 | Birmingham City | Derby County | 2-0 | 3 - 5 points |
| RLNO | 03/11/21 18:00 | 03/11/21 18:00 | Tennis Borussia Berlin | Tasmania Berlin | 0-0 | 3 - 5 points |
| RLB | 01/03/22 18:00 | 01/03/22 18:00 | SC Eltersdorf | SpVgg Greuther Fürth II | 0-3 | 3 - 5 points |