Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 22/10/21 01:20 | 22/10/21 01:20 | Cleveland Browns | Denver Broncos | 17-14 | 3 - 10 - 6 |
| 24/10/21 18:00 | 24/10/21 18:00 | Baltimore Ravens | Cincinnati Bengals | 17-41 | 3 - 10 - 10 |
| 24/10/21 18:00 | 24/10/21 18:00 | Miami Dolphins | Atlanta Falcons | 28-30 | 5 - 10 - 4 |
| 24/10/21 18:00 | 24/10/21 18:00 | Green Bay Packers | Washington Football Team | 24-10 | 3 - 10 - 10 |
| 24/10/21 18:00 | 24/10/21 18:00 | Tennessee Titans | Kansas City Chiefs | 27-3 | 4 - 10 - 4 |
| 24/10/21 18:00 | 24/10/21 18:00 | New England Patriots | New York Jets | 54-13 | 3 - 10 - 10 |
| 24/10/21 18:00 | 24/10/21 18:00 | New York Giants | Carolina Panthers | 25-3 | 7 - 10 - 3 |
| 24/10/21 21:05 | 24/10/21 21:05 | Las Vegas Raiders | Philadelphia Eagles | 33-22 | 3 - 10 - 8 |
| 24/10/21 21:05 | 24/10/21 21:05 | Los Angeles Rams | Detroit Lions | 28-19 | 3 - 10 - 10 |
| 24/10/21 21:25 | 24/10/21 21:25 | Tampa Bay Buccaneers | Chicago Bears | 38-3 | 3 - 10 - 10 |
| 24/10/21 21:25 | 24/10/21 21:25 | Arizona Cardinals | Houston Texans | 31-5 | 3 - 10 - 10 |
| 25/10/21 01:20 | 25/10/21 01:20 | San Francisco 49ers | Indianapolis Colts | 18-30 | 4 - 10 - 4 |
| 26/10/21 01:15 | 26/10/21 01:15 | Seattle Seahawks | New Orleans Saints | 10-13 | 6 - 10 - 3 |