Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 08/10/21 01:20 | 08/10/21 01:20 | Seattle Seahawks | Los Angeles Rams | 17-26 | 4 - 10 - 4 |
| 10/10/21 14:30 | 10/10/21 14:30 | Atlanta Falcons | New York Jets | 27-20 | 3 - 10 - 5 |
| 10/10/21 18:00 | 10/10/21 18:00 | Jacksonville Jaguars | Tennessee Titans | 19-37 | 10 - 10 - 3 |
| 10/10/21 18:00 | 10/10/21 18:00 | Carolina Panthers | Philadelphia Eagles | 18-21 | 3 - 10 - 8 |
| 10/10/21 18:00 | 10/10/21 18:00 | Pittsburgh Steelers | Denver Broncos | 27-19 | 4 - 10 - 4 |
| 10/10/21 18:00 | 10/10/21 18:00 | Cincinnati Bengals | Green Bay Packers | 22-25OT | 8 - 10 - 3 |
| 10/10/21 18:00 | 10/10/21 18:00 | Tampa Bay Buccaneers | Miami Dolphins | 45-17 | 3 - 10 - 10 |
| 10/10/21 18:00 | 10/10/21 18:00 | Houston Texans | New England Patriots | 22-25 | 10 - 10 - 3 |
| 10/10/21 18:00 | 10/10/21 18:00 | Washington Football Team | New Orleans Saints | 22-33 | 5 - 10 - 4 |
| 10/10/21 18:00 | 10/10/21 18:00 | Minnesota Vikings | Detroit Lions | 19-17 | 3 - 10 - 10 |
| 10/10/21 21:05 | 10/10/21 21:05 | Los Angeles Chargers | Cleveland Browns | 47-42 | 4 - 10 - 5 |
| 10/10/21 21:05 | 10/10/21 21:05 | Las Vegas Raiders | Chicago Bears | 9-20 | 3 - 10 - 10 |
| 10/10/21 21:25 | 10/10/21 21:25 | Dallas Cowboys | New York Giants | 44-20 | 3 - 10 - 10 |
| 10/10/21 21:25 | 10/10/21 21:25 | Arizona Cardinals | San Francisco 49ers | 17-10 | 3 - 10 - 6 |
| 11/10/21 01:20 | 11/10/21 01:20 | Kansas City Chiefs | Buffalo Bills | 20-38 | 4 - 10 - 4 |
| 12/10/21 01:15 | 12/10/21 01:15 | Baltimore Ravens | Indianapolis Colts | 31-25OT | 3 - 10 - 10 |