Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 24/09/21 01:20 | 24/09/21 01:20 | Houston Texans | Carolina Panthers | 9-24 | 7 - 10 - 3 |
| 26/09/21 18:00 | 26/09/21 18:00 | Jacksonville Jaguars | Arizona Cardinals | 19-31 | 10 - 10 - 3 |
| 26/09/21 18:00 | 26/09/21 18:00 | New England Patriots | New Orleans Saints | 13-28 | 4 - 10 - 5 |
| 26/09/21 18:00 | 26/09/21 18:00 | Detroit Lions | Baltimore Ravens | 17-19 | 10 - 10 - 3 |
| 26/09/21 18:00 | 26/09/21 18:00 | Cleveland Browns | Chicago Bears | 26-6 | 3 - 10 - 10 |
| 26/09/21 18:00 | 26/09/21 18:00 | Pittsburgh Steelers | Cincinnati Bengals | 10-24 | 3 - 10 - 8 |
| 26/09/21 18:00 | 26/09/21 18:00 | Kansas City Chiefs | Los Angeles Chargers | 24-30 | 3 - 10 - 10 |
| 26/09/21 18:00 | 26/09/21 18:00 | New York Giants | Atlanta Falcons | 14-17 | 4 - 10 - 5 |
| 26/09/21 18:00 | 26/09/21 18:00 | Tennessee Titans | Indianapolis Colts | 25-16 | 3 - 10 - 8 |
| 26/09/21 18:00 | 26/09/21 18:00 | Buffalo Bills | Washington Football Team | 43-21 | 3 - 10 - 10 |
| 26/09/21 21:05 | 26/09/21 21:05 | Las Vegas Raiders | Miami Dolphins | 31-28OT | 3 - 10 - 8 |
| 26/09/21 21:05 | 26/09/21 21:05 | Denver Broncos | New York Jets | 26-0 | 3 - 10 - 10 |
| 26/09/21 21:25 | 26/09/21 21:25 | Los Angeles Rams | Tampa Bay Buccaneers | 34-24 | 4 - 10 - 4 |
| 26/09/21 21:25 | 26/09/21 21:25 | Minnesota Vikings | Seattle Seahawks | 30-17 | 5 - 10 - 3 |
| 27/09/21 01:20 | 27/09/21 01:20 | San Francisco 49ers | Green Bay Packers | 28-30 | 4 - 10 - 4 |
| 28/09/21 01:15 | 28/09/21 01:15 | Dallas Cowboys | Philadelphia Eagles | 41-21 | 3 - 10 - 9 |