Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/12/21 01:20 | 17/12/21 01:20 | Los Angeles Chargers | Kansas City Chiefs | 28-34OT | 6 - 10 - 3 |
| 19/12/21 01:15 | 19/12/21 01:15 | Indianapolis Colts | New England Patriots | 27-17 | 5 - 10 - 4 |
| 19/12/21 18:00 | 19/12/21 18:00 | Buffalo Bills | Carolina Panthers | 31-14 | 3 - 10 - 10 |
| 19/12/21 18:00 | 19/12/21 18:00 | Miami Dolphins | New York Jets | 31-24 | 3 - 10 - 10 |
| 19/12/21 18:00 | 19/12/21 18:00 | Detroit Lions | Arizona Cardinals | 30-12 | 10 - 10 - 3 |
| 19/12/21 18:00 | 19/12/21 18:00 | Pittsburgh Steelers | Tennessee Titans | 19-13 | 4 - 10 - 4 |
| 19/12/21 18:00 | 19/12/21 18:00 | Jacksonville Jaguars | Houston Texans | 16-30 | 4 - 10 - 4 |
| 19/12/21 18:00 | 19/12/21 18:00 | New York Giants | Dallas Cowboys | 6-21 | 10 - 10 - 3 |
| 19/12/21 21:05 | 19/12/21 21:05 | San Francisco 49ers | Atlanta Falcons | 31-13 | 3 - 10 - 10 |
| 19/12/21 21:05 | 19/12/21 21:05 | Denver Broncos | Cincinnati Bengals | 10-15 | 4 - 10 - 4 |
| 19/12/21 21:25 | 19/12/21 21:25 | Baltimore Ravens | Green Bay Packers | 30-31 | 8 - 10 - 3 |
| 20/12/21 01:20 | 20/12/21 01:20 | Tampa Bay Buccaneers | New Orleans Saints | 0-9 | 3 - 10 - 10 |
| 20/12/21 22:00 | 20/12/21 22:00 | Cleveland Browns | Las Vegas Raiders | 14-16 | 3 - 10 - 6 |
| 21/12/21 01:15 | 21/12/21 01:15 | Chicago Bears | Minnesota Vikings | 9-17 | 6 - 10 - 3 |
| 22/12/21 00:00 | 22/12/21 00:00 | Philadelphia Eagles | Washington Football Team | 27-17 | 4 - 10 - 5 |
| 22/12/21 00:00 | 22/12/21 00:00 | Los Angeles Rams | Seattle Seahawks | 20-10 | 3 - 10 - 10 |