Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 25/11/21 17:30 | 25/11/21 17:30 | Detroit Lions | Chicago Bears | 14-16 | 5 - 10 - 3 |
| 25/11/21 21:30 | 25/11/21 21:30 | Dallas Cowboys | Las Vegas Raiders | 33-36OT | 3 - 10 - 10 |
| 26/11/21 01:20 | 26/11/21 01:20 | New Orleans Saints | Buffalo Bills | 6-31 | 6 - 10 - 3 |
| 28/11/21 18:00 | 28/11/21 18:00 | Jacksonville Jaguars | Atlanta Falcons | 14-21 | 4 - 10 - 4 |
| 28/11/21 18:00 | 28/11/21 18:00 | Cincinnati Bengals | Pittsburgh Steelers | 41-10 | 4 - 10 - 5 |
| 28/11/21 18:00 | 28/11/21 18:00 | New England Patriots | Tennessee Titans | 36-13 | 3 - 10 - 6 |
| 28/11/21 18:00 | 28/11/21 18:00 | Miami Dolphins | Carolina Panthers | 33-10 | 5 - 10 - 4 |
| 28/11/21 18:00 | 28/11/21 18:00 | New York Giants | Philadelphia Eagles | 13-7 | 8 - 10 - 3 |
| 28/11/21 18:00 | 28/11/21 18:00 | Houston Texans | New York Jets | 14-21 | 3 - 10 - 7 |
| 28/11/21 18:00 | 28/11/21 18:00 | Indianapolis Colts | Tampa Bay Buccaneers | 31-38 | 5 - 10 - 4 |
| 28/11/21 21:05 | 28/11/21 21:05 | Denver Broncos | Los Angeles Chargers | 28-13 | 8 - 10 - 3 |
| 28/11/21 21:25 | 28/11/21 21:25 | San Francisco 49ers | Minnesota Vikings | 34-26 | 4 - 10 - 4 |
| 28/11/21 21:25 | 28/11/21 21:25 | Green Bay Packers | Los Angeles Rams | 36-28 | 4 - 10 - 4 |
| 29/11/21 01:20 | 29/11/21 01:20 | Baltimore Ravens | Cleveland Browns | 16-10 | 3 - 10 - 8 |
| 30/11/21 01:15 | 30/11/21 01:15 | Washington Football Team | Seattle Seahawks | 17-15 | 4 - 10 - 4 |