Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 19/11/21 01:20 | 19/11/21 01:20 | Atlanta Falcons | New England Patriots | 0-25 | 10 - 10 - 3 |
| 21/11/21 18:00 | 21/11/21 18:00 | Chicago Bears | Baltimore Ravens | 13-16 | 7 - 10 - 3 |
| 21/11/21 18:00 | 21/11/21 18:00 | Minnesota Vikings | Green Bay Packers | 34-31 | 6 - 10 - 3 |
| 21/11/21 18:00 | 21/11/21 18:00 | Tennessee Titans | Houston Texans | 13-22 | 3 - 10 - 10 |
| 21/11/21 18:00 | 21/11/21 18:00 | Jacksonville Jaguars | San Francisco 49ers | 10-30 | 10 - 10 - 3 |
| 21/11/21 18:00 | 21/11/21 18:00 | Cleveland Browns | Detroit Lions | 13-10 | 3 - 10 - 10 |
| 21/11/21 18:00 | 21/11/21 18:00 | Buffalo Bills | Indianapolis Colts | 15-41 | 3 - 10 - 7 |
| 21/11/21 18:00 | 21/11/21 18:00 | Carolina Panthers | Washington Football Team | 21-27 | 3 - 10 - 6 |
| 21/11/21 18:00 | 21/11/21 18:00 | New York Jets | Miami Dolphins | 17-24 | 6 - 10 - 3 |
| 21/11/21 18:00 | 21/11/21 18:00 | Philadelphia Eagles | New Orleans Saints | 40-29 | 4 - 10 - 4 |
| 21/11/21 21:05 | 21/11/21 21:05 | Las Vegas Raiders | Cincinnati Bengals | 13-32 | 4 - 10 - 4 |
| 21/11/21 21:25 | 21/11/21 21:25 | Kansas City Chiefs | Dallas Cowboys | 19-9 | 4 - 10 - 4 |
| 21/11/21 21:25 | 21/11/21 21:25 | Seattle Seahawks | Arizona Cardinals | 13-23 | 5 - 10 - 4 |
| 22/11/21 01:20 | 22/11/21 01:20 | Los Angeles Chargers | Pittsburgh Steelers | 41-37 | 3 - 10 - 6 |
| 23/11/21 01:15 | 23/11/21 01:15 | Tampa Bay Buccaneers | New York Giants | 30-10 | 3 - 10 - 10 |