Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 25/11/25 17:45 | 25/11/25 17:45 | Ferencváros | Benfica | 33-31 | 2 - 17 points |
| 25/11/25 17:45 | 25/11/25 17:45 | HC Kriens-Luzern | Elverum Håndball | 34-38 | 2 - 17 points |
| 25/11/25 17:45 | 25/11/25 17:45 | IK Sävehof | Presov | 33-28 | 2 - 17 points |
| 25/11/25 17:45 | 25/11/25 17:45 | Minaur Baia Mare | Slovan | 28-22 | 2 - 17 points |
| 25/11/25 17:45 | 25/11/25 17:45 | MT Melsungen | Karlskrona | 35-34 | 2 - 17 points |
| 25/11/25 17:45 | 25/11/25 17:45 | Partizan | RK Našice | 30-27 | 2 - 17 points |
| 25/11/25 17:45 | 25/11/25 17:45 | Skanderborg AGF | BM Granollers | 28-29 | 2 - 17 points |
| 25/11/25 17:45 | 25/11/25 17:45 | St. Raphael | SG Flensburg-Handewitt | 29-36 | 2 - 17 points |
| 25/11/25 19:45 | 25/11/25 19:45 | Ademar León | Kadetten Schaffhausen | 30-27 | 2 - 17 points |
| 25/11/25 19:45 | 25/11/25 19:45 | CD Bidasoa Irún | Potaissa Turda | 35-30 | 2 - 17 points |
| 25/11/25 19:45 | 25/11/25 19:45 | IFK Kristianstad | Toulouse | 34-26 | 2 - 17 points |
| 25/11/25 19:45 | 25/11/25 19:45 | Montpellier Handball | BSV Bern Muri | 37-29 | 2 - 17 points |
| 25/11/25 19:45 | 25/11/25 19:45 | Ostrow Wielkopolski | THW Kiel | 25-33 | 2 - 17 points |
| 25/11/25 19:45 | 25/11/25 19:45 | Porto | Fram | 44-30 | 2 - 17 points |
| 25/11/25 19:45 | 25/11/25 19:45 | Sesvete | Vardar 1961 | 24-38 | 2 - 17 points |
| 25/11/25 19:45 | 25/11/25 19:45 | TSV Hannover-Burgdorf | Fredericia HK | 31-34 | 2 - 17 points |