Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/11/25 16:00 | 11/11/25 16:00 | Minaur Baia Mare | Skanderborg AGF | 27-45 | 2 - 17 points |
| 11/11/25 17:45 | 11/11/25 17:45 | Elverum Håndball | Porto | 25-29 | 2 - 17 points |
| 11/11/25 17:45 | 11/11/25 17:45 | HC Kriens-Luzern | Fram | 40-25 | 2 - 17 points |
| 11/11/25 17:45 | 11/11/25 17:45 | IFK Kristianstad | Vardar 1961 | 32-31 | 2 - 17 points |
| 11/11/25 17:45 | 11/11/25 17:45 | MT Melsungen | Ferencváros | 33-27 | 2 - 17 points |
| 11/11/25 17:45 | 11/11/25 17:45 | Ostrow Wielkopolski | Montpellier Handball | 25-38 | 2 - 17 points |
| 11/11/25 17:45 | 11/11/25 17:45 | Partizan | Ademar León | 25-18 | 2 - 17 points |
| 11/11/25 17:45 | 11/11/25 17:45 | Potaissa Turda | SG Flensburg-Handewitt | 26-33 | 2 - 17 points |
| 11/11/25 17:45 | 11/11/25 17:45 | Presov | Fredericia HK | 27-34 | 2 - 17 points |
| 11/11/25 17:45 | 11/11/25 17:45 | Sesvete | Toulouse | 32-31 | 2 - 17 points |
| 11/11/25 17:45 | 11/11/25 17:45 | Slovan | BM Granollers | 29-34 | 2 - 17 points |
| 11/11/25 19:45 | 11/11/25 19:45 | BSV Bern Muri | THW Kiel | 27-35 | 2 - 17 points |
| 11/11/25 19:45 | 11/11/25 19:45 | Karlskrona | Benfica | 32-34 | 2 - 17 points |
| 11/11/25 19:45 | 11/11/25 19:45 | RK Našice | Kadetten Schaffhausen | 29-30 | 2 - 17 points |
| 11/11/25 19:45 | 11/11/25 19:45 | St. Raphael | CD Bidasoa Irún | 35-32 | 2 - 17 points |
| 11/11/25 19:45 | 11/11/25 19:45 | TSV Hannover-Burgdorf | IK Sävehof | 27-25 | 2 - 17 points |