Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 05/11/21 19:55 | 05/11/21 19:55 | AFC Sudbury | Colchester United | 0-4 | 5 - 7 points |
| 06/11/21 13:00 | 06/11/21 13:00 | Scunthorpe United | Doncaster Rovers | 0-1 | 5 - 7 points |
| 06/11/21 14:00 | 06/11/21 14:00 | FC Gillingham | Cheltenham Town | 1-1 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | FC Gateshead | Altrincham FC | 2-2 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | York City | Buxton FC | 0-1 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Wigan Athletic | Solihull Moors FC | 0-0 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Rotherham United | Bromley FC | 3-0 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | FC Morecambe | Newport County | 1-0 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Yate Town FC | Yeovil Town | 0-5 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | FC Chesterfield | Southend United | 3-1 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Crawley Town | Tranmere Rovers | 0-1 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Carlisle United | Horsham FC | 2-0 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Charlton Athletic | Havant and Waterlooville | 4-0 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Hayes and Yeading United F.C. | Sutton United | 0-1 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Kings Lynn FC | FC Walsall | 0-1 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Leyton Orient | Ebbsfleet United | 1-0 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Halifax Town | Maidenhead Utd | 7-4 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Fleetwood Town | Burton Albion | 1-2 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Milton Keynes Dons FC | Stevenage FC | 2-2 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | AFC Wimbledon | Guiseley FC | 1-0 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Ipswich Town | Oldham Athletic | 1-1 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | FC Port Vale | Accrington Stanley | 5-1 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | FC Portsmouth | Harrow Borough | 1-0 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Kidderminster Harriers | Grimsby Town | 1-0 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Crewe Alexandra | Swindon Town | 0-3 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Northampton Town | Cambridge United | 2-2 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Lincoln City | Bowers and Pitsea FC | 1-0 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | AFC Sunderland | Mansfield Town | 0-1 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Harrogate Town FC | AFC Wrexham | 2-1 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Boreham Wood | Eastleigh FC | 2-0 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Hartlepool United | Wycombe Wanderers | 2-2 | 5 - 7 points |
| 06/11/21 15:00 | 06/11/21 15:00 | Bradford City | Exeter City | 1-1 | 5 - 7 points |
| 06/11/21 17:15 | 06/11/21 17:15 | Banbury United | Barrow FC | 0-4 | 5 - 7 points |
| 07/11/21 12:15 | 07/11/21 12:15 | Sheffield Wednesday | Plymouth Argyle | 0-0 | 5 - 7 points |
| 07/11/21 13:00 | 07/11/21 13:00 | Oxford United | Bristol Rovers | 2-2 | 5 - 7 points |
| 07/11/21 15:00 | 07/11/21 15:00 | Stratford Town | Shrewsbury Town | 1-5 | 5 - 7 points |
| 07/11/21 15:00 | 07/11/21 15:00 | Bolton Wanderers | Stockport County | 2-2 | 5 - 7 points |
| 07/11/21 15:00 | 07/11/21 15:00 | FC Rochdale | Notts County | 1-1 | 5 - 7 points |
| 07/11/21 17:15 | 07/11/21 17:15 | St Albans City | Forest Green Rovers | 3-2 | 5 - 7 points |
| 08/11/21 19:45 | 08/11/21 19:45 | Dagenham and Redbridge | Salford City | 0-1 | 5 - 7 points |