Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 25/09/21 12:30 | 25/09/21 12:29 | Manchester United | Aston Villa | 0-1 | 2 - 4 points |
| 25/09/21 12:30 | 25/09/21 12:29 | Chelsea FC | Manchester City | 0-1 | 2 - 4 points |
| 25/09/21 15:00 | 25/09/21 14:59 | Leeds United | West Ham United | 1-2 | 2 - 4 points |
| 25/09/21 15:00 | 25/09/21 14:59 | Leicester City | Burnley FC | 2-2 | 2 - 4 points |
| 25/09/21 15:00 | 25/09/21 14:59 | Watford FC | Newcastle United | 1-1 | 2 - 4 points |
| 25/09/21 15:00 | 25/09/21 14:59 | Everton FC | Norwich City | 2-0 | 2 - 4 points |
| 25/09/21 17:30 | 25/09/21 17:29 | Brentford FC | Liverpool FC | 3-3 | 2 - 4 points |
| 26/09/21 14:00 | 26/09/21 13:59 | Southampton FC | Wolverhampton Wanderers | 0-1 | 2 - 4 points |
| 26/09/21 16:30 | 26/09/21 16:29 | Arsenal FC | Tottenham Hotspur | 3-1 | 2 - 4 points |
| 27/09/21 20:00 | 27/09/21 19:59 | Crystal Palace | Brighton and Hove Albion | 1-1 | 2 - 4 points |